Step-by-step instructions
- Preheat your oven to 350°F (175°C).
- In a skillet over medium heat, cook the ground beef and onion together until the meat is browned and the onion is soft. Drain any excess fat.
- Mix in the cream of mushroom soup, diced tomatoes, and taco seasoning until well combined.
- Spread the meat mixture evenly in a casserole dish.
- Open the biscuit dough and cut each biscuit into quarters. Arrange the biscuit pieces over the meat layer.
- Sprinkle the shredded cheddar cheese on top of the casserole.
- Bake for 25-30 minutes, or until the biscuit pieces are golden brown and cooked through.
- Serve warm and enjoy!
Best ways to enjoy it
To serve John Wayne Casserole, consider pairing it with a fresh green salad tossed in a light vinaigrette, or you might enjoy some warm cornbread on the side. For those who love a little kick, a dollop of sour cream or guacamole on top can elevate the dish. Feel free to serve it alongside tortilla chips for a fun crunch!
Storage and reheating tips
Leftovers are a delightful part of making casseroles like this one. Store any extras in an airtight container in the refrigerator, where they’ll keep for about 3-4 days. To reheat, simply place it in the oven at 350°F (175°C) until warmed through, or microwave individual portions until hot. If you want to freeze it, make sure it’s cooled completely before transferring to a freezer-safe container — it can last for up to three months!
Helpful cooking tips
For best results, be sure to brown the beef properly; this adds depth to the flavor. If you’re in a pinch for time, you can use pre-cooked ground beef. Experiment with the spices you use: adding cumin or smoked paprika can provide a fantastic twist to the traditional flavor profile. Also, let the casserole sit for a few minutes once it’s out of the oven; this helps everything set and makes serving easier.
Creative twists
Feeling adventurous? Here are some variations to try with this recipe:
- Vegetarian Option: Substitute the ground beef with lentils or a plant-based meat alternative.
- Add Extra Veggies: Toss in some diced bell peppers, corn, or mushrooms for added texture and flavor.
- Southern Flair: Swap the cream of mushroom for cream of chicken and add a bit of hot sauce for a Southern kick!

Common questions
How long does it take to prepare?
The total time for preparing John Wayne Casserole is about 25 to 30 minutes, followed by baking for another 25-30 minutes. It’s a solid choice for a quick meal.
Can I make it ahead of time?
Absolutely! You can assemble the casserole a day in advance and store it in the refrigerator. Just pop it in the oven when you’re ready to bake.
Is there a way to make it dairy-free?
Yes, you can use dairy-free variations of the soup and cheese, and try a plant-based biscuit dough for a completely dairy-free meal!
With its hearty filling and comforting flavors, John Wayne Casserole is sure to become a staple in your kitchen. Whether you’re enjoying it for dinner or serving it at a gathering, it’s a tasty dish that showcases the love of home cooking!






