Step-by-step instructions
- Preheat your oven to 375°F (190°C).
- Cook the lasagna sheets according to package instructions until al dente, then set aside.
- In a large skillet, combine the shrimp, crawfish tails, and crabmeat. Add the tablespoon of liquid crab boil and cook until the shrimp turn pink.
- In a baking dish, start layering: place a layer of lasagna sheets, a layer of seafood mixture, a layer of cheese, and a layer of Alfredo sauce.
- Repeat layering until all ingredients are used, ending with a generous layer of cheese on top.
- Bake in the preheated oven for 25-30 minutes or until bubbly and golden brown.
- Allow the lasagna to rest for a few minutes before slicing and serving.
Best ways to enjoy it
Serving seafood lasagna can be as delightful as making it. Here are some creative suggestions:
- Garnish: A sprinkle of fresh parsley or a squeeze of lemon can brighten up the dish.
- Pair with Sides: Serve it alongside a crisp green salad or garlic bread for a complete meal.
- Wine Pairing: A chilled glass of Chardonnay complements the rich flavors of the seafood beautifully.
Keeping leftovers fresh
To ensure you enjoy every last bite of your seafood lasagna, consider these storage tips:
- Refrigerate: Store leftovers in an airtight container in the fridge for up to 3 days.
- Freeze: If you need to store it longer, seafood lasagna can be frozen. Wrap it tightly in plastic wrap and foil, and it will last up to 3 months.
- Reheating: To reheat, bake from frozen at 350°F (175°C) until heated through, or microwave individual portions until hot. Always ensure the lasagna is heated to an internal temperature of 165°F (74°C) for safety.
Pro chef tips
Here are a few insider tips to elevate your seafood lasagna:
- Prepare Ahead: This dish can be assembled in advance. Just cover it and refrigerate until you’re ready to bake.
- Crack the Shell: If you’re a shellfish lover, feel free to mix in lobster or scallops for an upscale version.
- Don’t Rush the Cheese: Allow the cheese to melt completely during baking for that unique gooey experience.
Creative twists
Looking to mix things up? Here are some fun variations to try:
- Herb Infusion: Add fresh herbs like dill or basil to your seafood mixture for an aromatic touch.
- Spicy Kick: If you like heat, consider adding diced jalapeños or a sprinkle of red pepper flakes to the seafood filling.
- Cream Sauce Alternatives: Swap out the Alfredo for a béchamel sauce or a marinara for a completely different flavor profile.

Your questions answered
Q: How long does it take to prepare seafood lasagna?
A: Preparing the ingredients and assembling the lasagna should take about 30-40 minutes, with an additional 25-30 minutes for baking.
Q: Can I substitute different seafood?
A: Absolutely! Feel free to substitute shrimp or crab with other shellfish like scallops or even use just one type of seafood if preferred.
Q: Is seafood lasagna healthy?
A: While it contains rich ingredients, seafood is generally high in protein and healthy fats. You can make it healthier by using whole-grain pasta and adding vegetables.
With its layers of flavors and textures, seafood lasagna is bound to be a family favorite, and with these tips and variations, you’ll be able to customize it to your heart’s desire!






